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GHRP-2

Hormonal & Endocrine · Pralmorelin, KP-102, GPA-748, Growth Hormone Releasing Peptide-2

A synthetic growth hormone releasing peptide studied in models of GH secretion and used as a diagnostic research probe of pituitary function.

🔬 Research use only — not for human or veterinary use. K4 Elite does not provide dosing instructions.
Molecular Formula
C45H55N9O6
Molecular Weight
818.0 g/mol
PubChem
CID 6918245 ↗
Research Level
Well Researched
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GHRP-2 chemical structure

GHRP-2, also known as pralmorelin, is a synthetic hexapeptide of the growth hormone releasing peptide family. It incorporates non-natural D-amino acids and a naphthylalanine residue that provide metabolic stability and potent secretagogue activity in preclinical studies.

It has been studied both as a research secretagogue and, in some regions, as a diagnostic probe of pituitary growth hormone reserve, making it one of the better-characterized members of the GHRP class.

GHRP-2 acts as an agonist at the growth hormone secretagogue receptor (GHS-R1a), the endogenous ghrelin receptor, stimulating pulsatile growth hormone release from pituitary somatotrophs in preclinical and clinical study models.

Research indicates its GH-releasing action is synergistic with GHRH signaling and largely independent of somatostatin tone, which is why it has been used to probe pituitary responsiveness.

  • Growth hormone secretion — studied as a potent GHS-R1a agonist eliciting GH release [1].
  • Pituitary function testing — investigated as a diagnostic research probe of GH reserve [2].
  • GHRH synergy — examined for combined effects with GHRH on GH output [1].
  • Appetite and metabolic signaling — explored via the ghrelin receptor pathway [3].
  • Neuroendocrine regulation — characterized for interactions with somatostatin tone [1].
📋 How published studies were conducted — a research reference summarizing study designs from the literature. This is not usage, dosing, or administration guidance. K4 Elite does not provide dosing instructions; determining any research protocol is the sole responsibility of the qualified researcher.

In neuroendocrine studies, investigators administered GHRP-2 and measured peak growth hormone responses, comparing it with GHRH and with combined administration [1].

In diagnostic research, a GHRP-2 stimulation test was studied in adults, and researchers measured stimulated GH concentrations to assess pituitary function [2]. Separate work examined the compound's engagement of the ghrelin receptor and reported observations on appetite-related signaling [3]. These are reported study observations, listed for reference only.

Combinations examined in the research literature. Descriptive only — not a recommendation to combine compounds.

TesamorelinSynergistic
GHRH analogs plus GHRP peptides show additive GH release in research models.
HexarelinNeutral
A closely related GHRP-family secretagogue; typically compared for potency and profile.
GHRP-6Neutral
Same peptide family with differing potency and appetite signaling; usually studied comparatively.
CJC-1295Synergistic
GHRH-analog plus GHRP pairing is a standard growth hormone research design.
  1. Bowers CY et al., J Clin Endocrinol Metab 1990 (GHRP-2 GH release)
  2. Chihara K et al., Growth Horm IGF Res 2007 (GHRP-2 diagnostic test)
  3. Laferrere B et al., J Clin Endocrinol Metab 2005 (GHRP-2 and appetite)
What is another name for GHRP-2?
GHRP-2 is also known as pralmorelin, and by development codes such as KP-102 and GPA-748.
What class of compound is it?
It is a synthetic hexapeptide growth hormone releasing peptide that acts at the ghrelin/GHS-R1a receptor.
Why has it been used in pituitary testing research?
Its strong, GHRH-synergistic GH-releasing action made it useful as a diagnostic research probe of pituitary GH reserve.
How does it relate to ghrelin?
It is a synthetic agonist at the ghrelin receptor (GHS-R1a), which links it to both GH-release and appetite-signaling research.
Is this material intended for human use?
No. This entry describes a compound supplied strictly for in-vitro and laboratory research use only, not for human or veterinary use.
Disclaimer: This profile summarizes published preclinical and laboratory research for reference only. It is not medical advice and makes no claim of safety or efficacy in humans. Determining any research protocol is the sole responsibility of the qualified researcher. Products are sold strictly for in-vitro research and have not been evaluated by the FDA.