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Epithalon

Longevity & Anti-Aging · ['Epitalon', 'Epithalone', 'AEDG peptide', 'Ala-Glu-Asp-Gly']

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the pineal peptide epithalamin, studied in preclinical models for effects on telomerase activity, circadian regulation, and aging biomarkers.

🔬 Research use only — not for human or veterinary use. K4 Elite does not provide dosing instructions.
Molecular Formula
C14H22N4O9
Molecular Weight
390.35 g/mol
PubChem
CID 219042 ↗
Research Level
Emerging Research
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Epithalon chemical structure

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed by Russian researchers, notably Vladimir Khavinson, as a defined-sequence analog of epithalamin, a peptide extract of the pineal gland.

Preclinical research has focused on its reported influence on telomerase expression, circadian and melatonin regulation, and various biomarkers of aging in cell-culture and rodent systems. It is among the most studied of the short "bioregulator" peptides in the Russian gerontology literature.

Epithalon is provided as a research reference peptide. It has not been approved for clinical use by major Western regulatory agencies, and claims about lifespan derive from animal and in vitro studies.

The most cited proposed mechanism is induction of telomerase reverse transcriptase (TERT) activity, with in vitro reports describing telomere elongation in human somatic cell cultures exposed to the peptide. This has been proposed as a basis for its studied effects on cellular senescence.

Additional work describes epigenetic and gene-regulatory effects, including modulation of genes involved in melatonin synthesis and circadian rhythm, consistent with its origin as a pineal-derived peptide analog.

  • Induction of telomerase activity and telomere elongation in human cell cultures (Khavinson et al., 2003).
  • Effects on lifespan and spontaneous tumor incidence in rodent aging studies (Anisimov et al.).
  • Regulation of melatonin secretion and circadian rhythm in aged animals.
  • Antioxidant and biomarker-of-aging endpoints in preclinical models.
  • Gene-expression and epigenetic regulation studies of short bioregulator peptides.
📋 How published studies were conducted — a research reference summarizing study designs from the literature. This is not usage, dosing, or administration guidance. K4 Elite does not provide dosing instructions; determining any research protocol is the sole responsibility of the qualified researcher.

Khavinson and colleagues (2003) exposed cultures of human fetal fibroblasts to the AEDG peptide and reported induction of telomerase activity and elongation of telomeres, with an increase in the number of cell-population doublings compared with controls [1].

Anisimov and colleagues conducted long-term rodent studies administering epithalon-type peptides to aging mice and rats, using lifespan and spontaneous tumor incidence as endpoints, and reported effects on mean lifespan and tumor frequency at the doses studied in those cohorts [2].

Additional pineal-peptide studies in aged animals measured melatonin rhythm and circadian markers, reporting normalization of melatonin secretion patterns relative to untreated aged controls [3].

Combinations examined in the research literature. Descriptive only — not a recommendation to combine compounds.

MelatoninSynergistic
Epithalon's proposed circadian/pineal actions overlap with melatonin signaling in preclinical models.
Telomerase-pathway compoundsSynergistic
Proposed TERT-inducing activity may parallel other telomere-focused research agents.
Antioxidant agentsCompatible
Studied alongside antioxidant endpoints; no adverse interaction reported in the literature.
Other bioregulator peptidesNeutral
Frequently studied within the same peptide-bioregulator research program; direct interactions not defined.
  1. Khavinson et al., 2003, Bull Exp Biol Med (Epithalon telomerase)
  2. Anisimov et al., peptide bioregulators and aging (PubMed search)
  3. Khavinson, peptides and aging review (PubMed search)
  4. PubChem CID 219042 (Epitalon)
What is Epithalon?
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on the pineal peptide epithalamin, studied for effects on telomerase and aging biomarkers in preclinical models.
What is its proposed mechanism?
In vitro studies report induction of telomerase (TERT) activity and telomere elongation, along with effects on melatonin and circadian gene regulation.
Does research show it extends human lifespan?
No such claim is supported here. Lifespan-related findings come from rodent and cell-culture studies, not controlled human longevity trials.
Is Epithalon FDA approved?
No. It is not approved by major Western regulators and is treated as an investigational research peptide.
Can I take this product?
No. This peptide is sold strictly for laboratory research use only and is not a drug, supplement, or product for human or animal consumption.
Disclaimer: This profile summarizes published preclinical and laboratory research for reference only. It is not medical advice and makes no claim of safety or efficacy in humans. Determining any research protocol is the sole responsibility of the qualified researcher. Products are sold strictly for in-vitro research and have not been evaluated by the FDA.