GHK-Cu (Copper Peptide)

GHK-Cu is a human three-block peptide called glycyl-L-histidyl-L-lysine (Gly-His-Lys, GHK) joined to copper. It was first found as a factor in blood and later described as a peptide involved in rebuilding tissue. It holds onto copper about as tightly as the body's own copper-carrying proteins, and it has been widely studied in research on skin renewal and tissue repair [1][3].

How it works

Rather than acting on one single target, GHK-Cu is described in research as a copper carrier and a signal that helps guide tissue rebuilding. Studies report that it affects the making and breakdown of collagen (the main protein that gives skin and tissue structure) and glycosaminoglycans (moisture-holding molecules in tissue), and the enzymes that remodel tissue along with the proteins that block them [1]. Reviews of gene-activity studies report that GHK affects a wide range of pathways linked to rebuilding and renewal [1].

Skin, collagen, and anti-aging research

GHK-Cu has the most skin research of the copper peptides. Cell studies report that it prompts fibroblasts (the cells that build connective tissue) to make more collagen, and one study using copper-free GHK looked at effects that helped skin stem cells recover [2]. Reviews summarize reported skin-rebuilding and renewal effects in test-tube and animal studies [1].

Wound healing research

In a rat study using a small wound chamber, GHK-Cu led to more connective-tissue buildup (measured by dry weight, DNA, and protein), and more of it built up as the dose went up [4]. GHK-peptide-loaded collagen matrices have been studied as materials to help skin wounds heal in rats [5], and copper-peptide complexes have been studied in guinea-pig skin wounds and fibroblast tests [6].

Hair and other research

Copper peptides have also been mentioned in hair and skin-care research, reflecting reported effects on tissue linked to hair follicles and connective tissue [2].

What the research hasn't shown yet

Most GHK-Cu evidence comes from test-tube or animal studies; controlled human data on how well it works and how safe it is are limited. This product is supplied strictly for laboratory research use only and is not a cosmetic or medical product.

For laboratory use, lyophilized GHK-Cu powder is typically reconstituted with sterile water. As a copper complex it should be protected from light and handled to avoid contamination with chelators. Store the lyophilized powder at -20°C for long-term stability; keep reconstituted solutions at 2-8°C and use within a short working window. Aliquot to minimize freeze-thaw cycles and avoid elevated temperatures.